Neural stem cells and its role in brain repair


Journal of Brain Research, is a peer reviewed, open access journal, This open access journal is published by OMICS International who hosts around 400 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. As a Managing Editor it is my great pleasure and honor to welcome you to submit your valuable research work to our Journal.

Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia of the nervous system of all animals during embryonic development.

Stem cells are characterized by their capacity to differentiate into multiple cell types.

NSCs has elucidated a wide array of beneficial properties of these cells. This has led to major strides in the field in harnessing their restorative, regenerative, and protective potential for the development of pre-clinical therapies in the treatment of many common and devastating neurodegenerative diseases, such as: spinal cord injury (SCI), Parkinson’s disease (PD), Alzheimer’s disease (AD), multiple sclerosis (MS) , amyotrophic lateral sclerosis (ALS).

NSC grafts only function through structural cell replacement has been recalibrated over the past decade with research demonstrating their capabilities to sense diverse signals, migrate to specific biological niches, and execute complex behaviors.

NSCs are being extensively investigated for their capacity to signal to the endogenous host cells upon transplantation, reduce chronic inflammation and promote regeneration in experimental CNS diseases. NSC transplantation, sustained graft-to-host exchanges of signals has led to trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses that have ultimately promoted the healing of the injured CNS.

NSC transplantation in neurodegenerative disorders:

NSCs are self-renewing, multi-potent cells characterized by their capacity to differentiate into multiple cell types, including astrocytes, oligodendrocytes, and neurons, making them an ideal therapeutic candidate for neurodegenerative disorders.

The initial success of transplantation studies in laboratory research is largely attributed to the immunological compatibility between the donor cells and the host. Allografts, where the transplanted cells and the host are not genetically identical, but members of the same species is most commonly performed in the lab.

Spinal cord injury:

spinal cord injury (SCI) research has made it abundantly clear that the ability to design treatments that induce long-distance regeneration of injured axons to improve function has remained elusive.

Ischemic stroke:

The global burden of stroke is immense, being the second leading cause of death and major disability worldwide with rising incidence rates due to an ever-increasing aged population.

Alzheimer’s disease:

Alzheimer’s disease (AD) is the most associated pathology with dementia and has been the focus of intense investigative efforts to develop clinically useful therapies to combat the significant social, economic, and medical impacts of this disease.

The Journal emphasizes high-level research and education Original research articles, reviews, short communications, and letters to the editors in the fields of Neurosciences are welcome. Every effort is made to have a speedy and critical peer-review process.

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