Are Macrophages Responsible for Cancer Metastasis?


Are Macrophages Responsible for Cancer Metastasis?

Journal of Immunobiology (Hilaris Publishing S.L) has announced almost 50 % discount on article processing charge to commemorate its 10th Anniversary.

Journal of Immunobiology is an open access, peer-reviewed journal that focuses and welcomes submissions on all aspects of Immunobiology, Immunology, Autoimmunity, Innate Immunity, Adaptive Immunity, immunization, Immunogenetics, Immune Disorders, Immunodeficiency, Immune inflammation, Immunoinformatics,  Clinical Immunology, Allergy & Immunology, Clinical & Vaccine Immunology,  Inflammatory Disorders, Autoimmune Disorders, Immunotherapy and Immunopathology of infectious, allergic and autoimmune disease etc.  

It gives us great pleasure to announce the call for paper on the occasion of 10th Anniversary of the Journal at special and hefty discount of up to 50 % on one-time article processing charge. Prospective academicians and scientists are encouraged to utilize this opportunity to get their articles reviewed, processed and published at relatively faster pace and at lower charges. In addition to this, the authors who publish with us during the year-long celebrations will also be eligible for academic awards recommended by the editorial panel.

The Archive page contains wide variety of articles such as Research / Review / Case reports / short communication / Mini review / Prospective / Letter to Editors Etc. We would like introduce a Short Communication which has been spread to the widest audience of experts; and thus increased in readership, citations and altimetry score.

Title: “Are Macrophages Responsible for Cancer Metastasis?

Introduction: Despite the decades of basic and clinical research and countless scientists and laboratories involved, the origin of cancer and metastasis still remain unresolved. Currently, there are two dominating theories of the origin of cancer: genetic and metabolic. The proponents of “the cancer as a genetic disease” theory postulate that various factors or a combination of factors such as heredity, random mutagenesis, hypoxia, radiation, inflammation, age, carcinogens, oncogenes or viruses, cause damage/changes to nuclear DNA and these in turn lead to the transformation of normal cells into cancer cells. In contrast, the advocates of “the cancer as a metabolic disease” theory believe that the acquisition of cancer phenotype is a consequence of mitochondrial and cell respiration defects-the so called Warburg effect when cancer cells produce energy by lactic acid fermentation in contrast to normal cells, which oxidize pyruvate in mitochondria and that the genetic/DNA changes observed in cancer cells are just the secondary effects of respiratory malfunctions. In many cancers the deficient oxidative phosphorylation in mitochondria correlates with disappearance of mitochondrial cristae. It is worth mentioning here that mutations in tumor suppressor genes such as for example p53 are also known to cause mitochondrial and respiratory damage. The results of nuclear or cytoplasm and mitochondria transplantation experiments between cancer and normal cells support the metabolic/ mitochondrial theory of cancer origin: cytoplasm or mitochondria from normal cells transplanted into cancer cells suppress cancer phenotype and mitochondria from cancer cells transplanted into normal cells induce tumorigenesis.

To have a glance at the full length manuscript, you can visit us at our archive page and Currently, Journal’s Archive is holding not only normal issues but also focusing on special issues. The purpose of special issues is to publish the most exciting research with respect to the subjects of Immunology / Immunobiology and to provide a rapid turn-around time regarding reviewing and publishing, and to publicize the articles freely for research, teaching and reference purposes. Submit manuscript of your research articles or special issue articles online through manuscript submission or forwarded to the Editorial Office at

Media Person,

David Williams

Journal Coordinator

Journal of Immunobiology